Secondary Metabolites from Marine Bacterium Nocardiopsis Sp. (G057)
Main Article Content
Abstract
Seven compounds were isolated and characterized from the culture broth of the marine bacteria Nocardiopsis sp. (strain G057), which was isolated from sediment collecting at Cô Tô - Quảng Ninh. Their structures were determined by spectroscopic analysis including MS and 2D NMR, as well as by comparison with reported data in the literature. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds 1, 2 and 7 selectively inhibited Escherichia coli with a MIC value of 32, 64, 8 μg/mL, respectively. Compound 3 exhibited antimicrobial activity against several strains of both gram-positive and gram-negative bacteria.
Keywords
Nocardiopsis, marine microorganisms, antimicrobial activity, Cylo-(Leu-Pro), xanthone
Article Details
References
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[2]. A. Debbab, H. Aly, W. H. Lin, P. Proksch, Bioactive compounds from marine bacteria and fungi, Microb. Biotechnol. 3(5) (2010) 544-563.
[3]. W. Fenical, New pharmaceuticals from marine organisms, Trends Biotechnol. 15 (1997) 339-341.
[4]. Quyen Vu Thi, Van Hieu Tran, Huong Doan Thi Mai, Cong Vinh Le, Hong Minh Le, Brian T. Murphy, Van Minh Chau and Van Cuong Pham Secondary Metabolites from an Actinomycete in Vietnam's East Sea, Natural Product communication 11 (2016), 401-404.
[5]. C. Pfefferle, J. Breinholt, H. Gurtler, H. P. Fiedler, 1-Hydroxy-4-methoxy-2-naphthoic acid, a herbicidal compound produced by Streptosporangium cinnabarinum ATCC 31213. The Journal of Antibiotics 50 (1997) 1067-1068.
[6]. D. Akhmad, K. Soleh, B. S. K. Leonardus, and M. S. Yana, Scopoletin, a coumarin derivative compound isolated from Macaranga gigantifolia Merr, Journal of Applied Pharmaceutical Science 2 (2012) 175-177.
[7]. A. A. Vitale, G. P. Romanelli, J. C. Autino, A. B. Pomilio. A novel route for the preparation of xanthones and chromanones, Journal of Chemical Research. Synopses 2 (1994) 82-83.
[8]. F. Fdhila, V. Vazquez, J. L. Sanchez, R. Riguera, DD-Diketopiperazines. Antibiotics active against Vibrio anguillarum isolated from marine bacteria associated with cultures of Pecten maximus, J. Nat. Prod. 66 (2003) 1299-1301.
[9]. C. Y. Wang, L. Han, K. Kang, C. L. Shao, Y. X. Wei, C. J. Zheng and H. S. Guan, Secondary metabolites from green algae Ulva pertusa, Chem. Nat. Compd., 68 (2010) 828-830.
[10]. K. Nishanth, C. Mohandas, B. Nambisan, D. R. Soban Kumar, R. S. Lankalapalli, Isolation of proline-based cyclic dipeptides from Bacillus sp. N strain associated with rhabitid entomopathogenic nematode and its antimicrobial properties, World J Microbiol Biotechnol 29 (2013) 355-364.
[11]. M. Mitova, G. Tommonaro, U. Hentschel, W. E. G. Muller, S. De Rosa, Exocellular cyclic dipeptides from a Ruegeria strain associated with cell cultures of Suberites domuncula, Mar. Biotechnol. 6 (2004) 95-103.
[12]. G. Wang, S. Dai, M. Chen, H. Wu, L. Xie, X. Luo, X. Li. Two diketopiperazine cyclo(Pro-Phe) isomers from marine bacterium Bacillus subtilis sp. 13-2, Chem. Nat. Compd. 46 (2010) 583-585.
[13]. G. Venkateswara, C. Sharlene, and T. Mukhopadhyay, Secondary metabolites from the flowers of Mimusops elengi Linn., Der Pharmacia Lettre 4 (2012) 1817-1820.