Silver and Gold Nanoparticles: a Toxicological Aspect
Main Article Content
Abstract
Silver and gold nanoparticles have been found in vast number of applications, especially in medicine. With increasing and intensively uses of these nanoparticles, there is a growing concern, recently, on their environmental impacts when they are released into environments. In this study, the size and shape- dependent cytotoxicity of silver and gold nanoparticles have been examined. Silver nanoparticles inhibited the growth of the mold Aspergillus niger, and the one-dimension (Np1) and two-dimension (Np2) nanoparticles indicated more effective than the round ones (Np0). On the other hand, gold nanoparticles of the three types: nanostars (AuNS), polyethylene glycol coated nanostars (PEG-NS) and TAT peptide tagged nanostars (TAT-NS), placed impact on the BT549 human breast cancer cells with reduction in the cell viability. The PEG-NS showed more remarkable impact on the cells in compare to the others.
Keywords
Silver nanoparticles, Gold nanoparticles, Toxicity
Article Details
References
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[3] Taylor E. and Webster T. J. Reducing infection through nanotechnology and NPs. Int J Nanomed. 6 (2011): 1463-1473.
[4] Austin L. A. et al. The optical, photothermal, and facile surface chemical properties of gold and silver NPs in biodiagnostics, therapy and drug delivery. Arch Toxicol. 88 (2014): 1391-1417.
[5] Ge L. et al. Nanosilver particles in medical applications: synthesis, performance and toxicity. Int J Nanomed. 9 (2014): 2399-2407.
[6] Srisam M. et al. Single Nanoparticles Plasmonic Sensors. Sensors 15 (2015):22774-22792.
[7] Calixto G. M. F. et al. Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review. Molecules 21 (2016):342.
[8] Mocan L. et al. Advances in cancer research using gold nanoparticles mediated photothermal ablation. Clujul Medical 89(2) (2016):199-202.
[9] Vo-Dinh T. et al. Plasmonic Nanoprobes: From Chemical Sensing to Medical Diagnostics and Therapy. Nanoscales 5(21) (2013):10127-10140.
[10] Bucharskaya A. et al. Towards Effective Photothermal/Photodynamic Treatments Using Plasmonic Gold Nanoparticles. Int. J. Mol. Sci. 17 (2016):1295.
[11] Fröhlich E. Value of phagocyte function screening for immunotoxicity of NPs in vivo. Int J Nanomed. 10 (2015): 3761-3778.
[12] Katsnelson B. A. et al. Some inferences from in vivo experiments with metal and metal oxide NPs: the pulmonary phagocytosis response, subchronic systemic toxicity, genotoxicity, regulatory proposals, searching for bioprotectors (a self-overview). Int J Nanomed. 10 (2015): 3013-3029.
[13] Abdelhalim M. A. K. et al. Gold nanoparticles induced cloudy swelling to hydropic degeneration, cytoplasmic hyaline vacuolation, polymorphism, binucleation, karyopyknosis, karyolysis, karyorrhexis and necrosis in the liver. Lipids in Health and Disease 10 (2011):166.
[14] Ma X. et al. Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment. ACS Nano 5(11) (2011):8629-8639.
[15] Utembe W. et al. Dissolution and biodurability: Important parameters needed for risk assessment of nanomaterials. Particle and Fibre Toxicology 12 (2015): 11.
[16] Durenkamp M. et al. NPs within WWTP sludges have minimal impact on leachate quality and soil microbial community structure and function. Environ. Pollut. 211 (2016): 399-405.
[17] Zuverza-Mena N. et al. Effect of silver NPs on radish sprouts: Root growth reduction and modifications in the nutritional value. Front. Plant Sci. 7 (2016): 90.
[18] Yuan H. et al. TAT Peptide-Functionalized Gold Nanostars: Enhanced Intracellular Delivery and Efficient NIR Photothermal Therapy Using Ultralow Irradiance. J. Am. Chem. Soc. 134 (2012): 11358-11361.
[19] Fales A. M. et al. Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering. J. Phys. Chem. 118 (2014): 3708-3715.
[20] McShan D. et al. Molecular Toxicity Mechanism of Nanosilver. J Food Drug Anal. 22(1) (2014): 116-127.
[21] Rinna A. et al. Effect of silver nanoparticles on mitogen-activated protein kinases activation: role of reactive oxygen species and implication in DNA damage. Mutagenesis 30 (2015): 59-66.
[22] Kaba S. 1. and Egorova E. M. In vitro studies of the toxic effects of silver nanoparticles on Hela and U937 cells. Nanotechnology, Science and Applications 8 (2015): 19-29.
[23] Bao H. et al. New Toxicity Mechanism of Silver Nanoparticles: Promoting Apoptosis and Inhibiting Proliferation. Plos ONE 10(3) (2015): e0122535.
[24] Lévy R. et al. Gold nanoparticles delivery in mammalian live cells: a critical review. Nano Reviews 1 (2010): 4889.
[25] Aillon K. L. et al. Effects of nanomaterial physicochemical properties on in vivo toxicity. Adv Drug Deliv Rev 61(6) (2009): 457-466.
[26] Ballou B. et al. Noninvasive imaging of quantum dots in mice. Bioconjug. Chem 15 (2004):79-86.
[27] Zhang X-D. et al. Size-dependent in vivo toxicity of PEG-coated gold nanoparticles. Int J Nanomed. 6 (2011):2071-2081.