Studying paracetamol and aspirin medicine by Raman spectroscopy
Main Article Content
Abstract
Raman spectral method is non-destructive analysis method, not sample preparation. This technique has recently been used for rapid test and for the detection of counterfeit drugs. In this article, we have used Raman spectral to study paracetamol and aspirin. We have developed five formulas for the preparation of paracetamol and aspirin active ingredients (5%, 10%, 15%, 20%, 25% and 50%) with types of excipient corresponding to 05 formulas. In this work, we also investigated the development of a qualitative analysis process and limited the detection of paracetamol and aspirin. The results can be used to test the quality of drugs in the market.
Keywords
Raman spectral, medicine counterfeit, paracetamol, aspirin
Article Details
References
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[2]. M.E. Auer, U.J. Griesser, J. Sawatzki, Qualitative and quantitative study of polymorphic forms in drug formulations by near infrared FT-Raman spectroscopy, Journal of Molecular Structure (2003) 307-317.
[3]. S.E. J. Bell, D.T. Burns, A.C. Dennis and J.S. Speers, Rapid analysis of ecstasy and related phenethylamines in seized tablets by Raman spectroscopy, Analyst 125 (2000) 541-544.
[4]. J. Arruabarrena, J. Coello, S. Maspoch, Raman spectroscopy as a complementary tool to assess the content uniformity of dosage units in break-scored warfarin tablets, International Journal of Pharmaceutics 465 (2014) 299 - 305.
[5]. K. Buckley, P. Matousek, Recent advances in the application of transmission Raman spectroscopy to pharmaceutical analysis, Journal of Pharmaceutical and Biomedical Analysis 55 (2011) 645 - 652.
[6]. A. Paudel, D. Raijada, J. Rantanen, Raman spectroscopy in pharmaceutical product design, Advanced Drug Delivery Reviews 89 (2015) 3 - 20.