Structural Elucidation of Some Phenolic Compounds from the Leaves of Kadsura Coccinea in Vietnam
Main Article Content
Abstract
Natural products and their derivatives represent more than 50% of all the drugs in modern therapeutics. Flavonoids and lignans are large group of naturally occurring and play a variety of biological activities in plants. Schisandraceae family includes 2 genera, Schisandra and Kadsura with about 39 species of plants. The Kadsura coccinea, belonging to Schisandraceae family, is mainly distributed in the tropical and subtropical regions of South and Southeast Asia. The aim of this study is the isolation and structural elucidation of compounds isolated from the leaves of Kadsura coccinea. For this purpose, five known flavonoid compounds, (+)-gallocatechin (1), catechin (2), (-)-epicatechin (3), phloretin-2-O-glucoside (4), phloretin-4-O-glucoside (5) together with 2-hydroxy-5-methoxyphenyl-O-β-D-glucopyranoside (6) and icariside E3 (7) were isolated. Their structures are elucidated by NMR spectroscopic analysis as well as compared with the literature. Especially, compound 6 is the first isolated from this plant.
Keywords
Kadsura coccinea, Schisandraceae, flavonoid, phenolic
Article Details
References
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[6] Tran Manh Hung, Nguyen Hai Dang, Tran Phuong Thao, Tran Phi Long, Jeong Hyung Lee, Le Phuoc Cuong, Pham Thanh Huyen, Phuong Thien Thuong, Cytotoxicity activity against pancreatic cancer cell lines of lanostane triterpenoids from the leaves of Kadsura coccinea (Lem.) A. C. Smith, Journal of Medicinal Materials, 23 (4), 210-216.
[7] A. M. Mendoza-Wilson, D. Glossman-Mitnik, Theoretical study of the molecular properties and chemical reactivity of (+)-catechin and (−)-epicatechin related to their antioxidant ability, Journal of Molecular Structure: Theochem, 761, 97–106, 2006. https://doi.org/10.1016/j.theochem.2006.01.001
[8] L. Wang, Z. W. Li, W. Zhang, R. Xu, F. Gao, Y.F. Liu, Y. J. Li, Synthesis, crystal structure, and biological evaluation of a series of phloretin, derivatives, Molecules, 19, 16447–16457, 2014. https://doi.org/10.3390/molecules191016447
[9] R. P. Pandey, T. F. Li, E. Kim, T. Yamaguchi, Y. I. Park, J. S. Kim, J. K. Sohng, Enzymatic synthesis of novel phloretin glucosides, Applied and Environmental Microbiology., 35166-3521, 2013. https://doi.org/10.1128/AEM.00409-13
[10] Y. Liu, Y. Yang, S. Tasneem, N. Hussain, M. Daniyal, H. Yuan, Q. Xie, B. Liu, J. Sun, Y. Jian, B. Li, S. Chen, and W. Wang, Lignans from TuJia Ethnomedicine Heilaohu: chemical characterization and evaluation of their cytotoxicity and antioxidant activities, Molecules 23, 2018 https://doi.org/10.3390/molecules23092147
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[12] M. K. Lee, S. H. Sung, H. S. Lee, J. H. Cho, and Y. C. Kim. Lignan and neolignan glycosides from Ulmus davidiana var. Japonica, Arch Pharm Res Vol 24, No 3, 198-201, 2001 https://doi.org/10.1007/BF02978256