PET Image Quality Evaluation at Upper and Lower Threshold of ¹⁸F-FDG dose: A Pilot Study in Vietnamese Patients
Main Article Content
Abstract
¹⁸F-FDG Positron Emission Tomography (PET) is the most common modality used in cancer diagnosis and monitoring. PET imaging results in patients being exposed to a certain level of radiation, which may be harmful to the body. Research has been conducted on reducing radiation dose in PET imaging in order to minimize radiation risks, at the same time still maintaining diagnostic image quality. This study was a pilot study conducted at the 108 Government Military Hospital in Hanoi, Vietnam, whereby randomly selected patients regardless of body weight were sent for whole body ¹⁸F-FDG PET imaging with a dose of 0.1 mCi/kg, which is the lower threshold in the recommended dose range in the guidelines on the Society of Nuclear Medicine and Molecular Imaging website. Another group of patients underwent the same PET procedure with dose calculation using the upper threshold of the same range (0.15 mCi/kg). Image quality, manifested through the Signal-to-Noise Ratio (SNR), was compared between the low-dose and high-dose groups. No statistically significant difference in image quality was revealed between the two groups, suggesting that dose reduction in a certain limit did not affect PET image quality.
Keywords
PET, ¹⁸F-FDG, BMI
Article Details
References
[1] Masuda Y., Kondo C. Matsuo Y., Uetani M. and Kusakabe, K. Comparison of imaging protocols for 18F-FDG PET/CT in overweight patients: optimizing scan duration versus administered dose. J Nucl Med. 2009 Jun;50(6):844-8.
[2] Sánchez-Jurado R., Devis M., Sanz R., Aguilar J.E., del Puig Cózar M., Ferrer-Rebolleda J. Whole-body PET/CT studies with lowered ¹⁸F-FDG doses: the influence of body mass index in dose reduction. J Nucl Med Technol. 2014 Mar;42(1):62-7.
[3] Geismar J.H., Stolzmann P., Sah B.R., Burger I.A., Seifert B., Delso G., von Schulthess G.K., Veit-Haibach P., Husmann L. Intra-individual comparison of PET/CT with different body weight-adapted FDG dosage regimens. Acta Radiol Open. 2015 Jan 29;4(2).
[4] PaiM.P. Drug dosing based on weight and body surface area: mathematical assumptions and limitations in obese adults. Pharmacotherapy. 2012 Sep;32(9):856-68
[5] Chang T., Chang G., Clark J.W., Diab R.H., Rohren E., Mawlawi O.R. Reliability of predicting image signal-to-noise ratio using noise equivalent count rate in PETim aging. Med Phys. 2012 Oct;39(10):5891-900.
[6] de Groot E.H., Post N., Boellaard R., Wagenaar N.R., Willemsen A.T., van Dalen J.A. Optimized dose regimen for whole-body FDG-PET imaging. EJNMMI Res. 2013 Aug 12;3(1):63.
[7] Menezes V.O., Machado M.A., Queiroz C.C., Souza S.O., d’Errico F., Namías M., Larocca T.F., Soares M.B.Optimization of oncological ¹⁸F-FDG PET/CT imaging based on a multiparameter analysis. Med Phys. 2016 Feb;43(2):930-8.
[8] McDermott G.M., Chowdhury F.U., Scarsbrook A.F.Evaluation of noise equivalent count parameters as indicators of adult whole-body FDG-PETimage quality. Ann Nucl Med. 2013 Nov;27(9):855-61
[2] Sánchez-Jurado R., Devis M., Sanz R., Aguilar J.E., del Puig Cózar M., Ferrer-Rebolleda J. Whole-body PET/CT studies with lowered ¹⁸F-FDG doses: the influence of body mass index in dose reduction. J Nucl Med Technol. 2014 Mar;42(1):62-7.
[3] Geismar J.H., Stolzmann P., Sah B.R., Burger I.A., Seifert B., Delso G., von Schulthess G.K., Veit-Haibach P., Husmann L. Intra-individual comparison of PET/CT with different body weight-adapted FDG dosage regimens. Acta Radiol Open. 2015 Jan 29;4(2).
[4] PaiM.P. Drug dosing based on weight and body surface area: mathematical assumptions and limitations in obese adults. Pharmacotherapy. 2012 Sep;32(9):856-68
[5] Chang T., Chang G., Clark J.W., Diab R.H., Rohren E., Mawlawi O.R. Reliability of predicting image signal-to-noise ratio using noise equivalent count rate in PETim aging. Med Phys. 2012 Oct;39(10):5891-900.
[6] de Groot E.H., Post N., Boellaard R., Wagenaar N.R., Willemsen A.T., van Dalen J.A. Optimized dose regimen for whole-body FDG-PET imaging. EJNMMI Res. 2013 Aug 12;3(1):63.
[7] Menezes V.O., Machado M.A., Queiroz C.C., Souza S.O., d’Errico F., Namías M., Larocca T.F., Soares M.B.Optimization of oncological ¹⁸F-FDG PET/CT imaging based on a multiparameter analysis. Med Phys. 2016 Feb;43(2):930-8.
[8] McDermott G.M., Chowdhury F.U., Scarsbrook A.F.Evaluation of noise equivalent count parameters as indicators of adult whole-body FDG-PETimage quality. Ann Nucl Med. 2013 Nov;27(9):855-61