Study on the Synthesis of Natural and Synthetic β-amino Alcohols with Biological Activity
Main Article Content
Abstract
β-Amino alcohols are important bifunctional compounds characterized by the presence of both amine and hydroxyl groups within the molecule, which contributes to their diverse biological activities. Numerous experimental and clinical studies have demonstrated that β-amino alcohols play a central role in the pharmacophoric structures of various clinically used drugs This study focuses on the synthesis of a series of β-amino alcohols via epoxide ring-opening reactions using both natural and synthetic building blocks, followed by an evaluation of their novel biological activities. A total of 10 β-amino alcohols were successfully synthesized, including 3 novel compounds reported for the first time. These compounds were evaluated for cytotoxic activity against four cancer cell lines: rhabdomyosarcoma (RD), human hepatocellular carcinoma (Hep-G2), lung cancer (Lu), and uterine cancer (Fl), as well as for antimicrobial activity against 8 microbial strains representing 4 groups: gram-negative bacteria, gram-positive bacteria, filamentous fungi, and yeasts. The results showed that the cytotoxic activity of the synthesized compounds was generally low, with only two compounds exhibiting weak activity and the remainder showing no activity. Although these findings do not support the anticancer potential of the compounds, they do suggest a favorable safety profile for exploring other biological applications. In contrast, the antimicrobial screening yielded promising results: five compounds demonstrated inhibitory effects against 1–3 microbial strains, and notably, one compound exhibited activity against five strains.
Keywords
anticancer, antimicrobial, organic synthesis, β-Amino alcohol, semi-synthesis, natrual compounds, epichlorhydrin ring opening
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
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