Some Chemical Components from Gnetum montanum Markgr. in Vietnam
Main Article Content
Abstract
Gnetum montanum Markgr.(Gnetaceae), Vietnamese name as Day gam, Gam nui is creeping and turning wood, distributed in natural forests at altitudes of 200-1200 m. It grows widely in mountainous areas in Vietnam. Its stem can disinfect, eliminate rheumatism, eliminate toxins in the body, and support the treatment of inflammation, blood disorders, leprosy, or joint pain in traditional medicine. In the course of study on the chemical composition of Gnetum montanum Markgr. in Vietnam, this paper described the extraction and structure evaluation of four compounds, including lehmbachol D (1), 3,4,5-trimethoxy-10,14-stibenediol (2), gnetucleistol C (3) and (+)-pinoresinol (4). The stems of this plant were collected, identified, dried and extracted in different polarity solvents. These substances were isolated from the ethyl acetate of methanol extract on the basis of column chromatography combined with thin layer chromatography. Their structures were identified based on spectroscopic evaluation and comparison of corresponding authentic compounds. Compound 2 was firstly recorded on the paper.
Keywords
Gnetum, G.montanum., stilbenes, stilbenediol
Article Details
References
[1] Wang, Yinghong & Huang, Kaisheng & Lin, Mao. Four new stilbene dimers from the lianas of Gnetum Hainanense, Journal of Asian Natural Products Research, vol. 3, pp. 169-176, 2001. https://doi.org/10.1080/10286020108041387
[2] Ibrahim Iliya, Zulfiqar Ali, Toshiyuki Tanaka, Munekazu Iinuma, Miyuki Furusawa, Ken-ichi Nakaya, Jin Murata, Dedy Darnaedi. Stilbenoids from the stem of Gnetum latifolium (Gnetaceae), Phytochemistry, vol. 61, issue 8, pp. 959-961, 2002. https://doi.org/10.1016/S0031-9422(02)00289-3
[3] Saisin S., Tip-pyang S., Phuwapraisirisan P., A new antioxidant flavonoid from the lianas of Gnetum macrostachyum, Nat Prod Res., vol. 23, issue 16, pp. 1472-7, Oct. 2009. https://doi.org/10.1080/14786410802280943
[4] Qin Wang, L., Xing Zhao, Y., Zhou, L et al.. Lignans from Gnetum montanum Markgr.f.megalocarpua, Chem Nat Compd, vol. 45, pp. 424–426, Aug. 2009. https://doi.org/10.1007/s10600-009-9325-y
[5] Sakagami Y., Sawabe A., Komemushi S., All Z., Tanaka T., Iliya I., Iinuma M., Antibacterial activity of stilbene oligomers against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) and their synergism with antibiotics, Biocontrol Sci., vol. 12, issue 1, pp. 7-14, Mar. 2007. https://doi.org/10.4265/bio.12.7
[6] Cheng, Ka-Wing & Wang, Mingfu & Chen, Feng & Ho, Chi-Tang. Oligostilbenes from Gnetum species and anticarcinogenic and antiinflammatory activities of oligostilbenes, ACS Symposium Series, vol. 987, pp. 36-58, Sep. 2008. https://doi.org/10.1021/bk-2008-0987.ch004
[7] Li X. M., Lin M., Wang Y. H., Liu X., Four new stilbenoids from the lianas of Gnetum montanum f. megalocarpum, Planta Med, vol. 70(2): pp. 160-165, Feb. 2004. https://doi.org/10.1055/s-2004-815494
[8] Qin Wang, L., Xing Zhao, Y., Zhou, L., et al. Lignans from Gnetum montanum Markgr.f.megalocarpua, Chem Nat Compd, vol. 45, pp. 424–426, May. 2009. https://doi.org/10.1007/s10600-009-9325-y
[9] Vu Thi Lan Phuong, Research on chemical compositions of Gnetum montanum Markgr, Hai Phong University Science Journal vol. 34(5), pp. 45-50, 2019.
[10] Luong Thi Thu Hien, Nguyen Van Hung, Nguyen Thi Minh Hang, Tran Huu Giap, Vu Thi Kim Oanh, Le Nguyen Thanh. Some stilbene compounds isolated from the medicinal plant Gnetum montanum Markgr, Vietnamese Pharmaceutical Journal, vol. 58, pp. 29-32, 2018.
[11] Kazuyoshi Kawazoe, Naoko Shimogai, Yoshihisa Takaishi, K. Sundar Rao, Yasuhiro Imakura. Four stilbenes from Salacia lehmbachii. Phytochemistry, vol. 44, issue 8, pp. 1569-1573, Apr. 1997. https://doi.org/10.1016/S0031-9422(96)00768-6
[12] Shenyang Agri. Univ., Dracaena cochinchinensis extract with bacteriostatic function as well as preparation and application thereof, China Patent CN 110041166, 2021.
[13] Chun-Suo Yao, Mao Lin, Xin Liu, Ying-Hong Wang. Stilbene derivatives from Gnetum cleistostachyum. Journal of Asian Natural Products Research, vol. 7, issue 2, pp. 131-137, 2005. https://doi.org/10.1080/10286020310001625102
[14] B. Vermes, O. Seligmann, H. Wagner. Synthesis of biologically active tetrahydro-furofuranlignan-(syringin, pinoresinol)- mono- and bis-glucosides. Phytochemistry, vol. 30, issue 9, pp. 3087-3089, 1991. https://doi.org/10.1016/S0031-9422(00)98258-X
[2] Ibrahim Iliya, Zulfiqar Ali, Toshiyuki Tanaka, Munekazu Iinuma, Miyuki Furusawa, Ken-ichi Nakaya, Jin Murata, Dedy Darnaedi. Stilbenoids from the stem of Gnetum latifolium (Gnetaceae), Phytochemistry, vol. 61, issue 8, pp. 959-961, 2002. https://doi.org/10.1016/S0031-9422(02)00289-3
[3] Saisin S., Tip-pyang S., Phuwapraisirisan P., A new antioxidant flavonoid from the lianas of Gnetum macrostachyum, Nat Prod Res., vol. 23, issue 16, pp. 1472-7, Oct. 2009. https://doi.org/10.1080/14786410802280943
[4] Qin Wang, L., Xing Zhao, Y., Zhou, L et al.. Lignans from Gnetum montanum Markgr.f.megalocarpua, Chem Nat Compd, vol. 45, pp. 424–426, Aug. 2009. https://doi.org/10.1007/s10600-009-9325-y
[5] Sakagami Y., Sawabe A., Komemushi S., All Z., Tanaka T., Iliya I., Iinuma M., Antibacterial activity of stilbene oligomers against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) and their synergism with antibiotics, Biocontrol Sci., vol. 12, issue 1, pp. 7-14, Mar. 2007. https://doi.org/10.4265/bio.12.7
[6] Cheng, Ka-Wing & Wang, Mingfu & Chen, Feng & Ho, Chi-Tang. Oligostilbenes from Gnetum species and anticarcinogenic and antiinflammatory activities of oligostilbenes, ACS Symposium Series, vol. 987, pp. 36-58, Sep. 2008. https://doi.org/10.1021/bk-2008-0987.ch004
[7] Li X. M., Lin M., Wang Y. H., Liu X., Four new stilbenoids from the lianas of Gnetum montanum f. megalocarpum, Planta Med, vol. 70(2): pp. 160-165, Feb. 2004. https://doi.org/10.1055/s-2004-815494
[8] Qin Wang, L., Xing Zhao, Y., Zhou, L., et al. Lignans from Gnetum montanum Markgr.f.megalocarpua, Chem Nat Compd, vol. 45, pp. 424–426, May. 2009. https://doi.org/10.1007/s10600-009-9325-y
[9] Vu Thi Lan Phuong, Research on chemical compositions of Gnetum montanum Markgr, Hai Phong University Science Journal vol. 34(5), pp. 45-50, 2019.
[10] Luong Thi Thu Hien, Nguyen Van Hung, Nguyen Thi Minh Hang, Tran Huu Giap, Vu Thi Kim Oanh, Le Nguyen Thanh. Some stilbene compounds isolated from the medicinal plant Gnetum montanum Markgr, Vietnamese Pharmaceutical Journal, vol. 58, pp. 29-32, 2018.
[11] Kazuyoshi Kawazoe, Naoko Shimogai, Yoshihisa Takaishi, K. Sundar Rao, Yasuhiro Imakura. Four stilbenes from Salacia lehmbachii. Phytochemistry, vol. 44, issue 8, pp. 1569-1573, Apr. 1997. https://doi.org/10.1016/S0031-9422(96)00768-6
[12] Shenyang Agri. Univ., Dracaena cochinchinensis extract with bacteriostatic function as well as preparation and application thereof, China Patent CN 110041166, 2021.
[13] Chun-Suo Yao, Mao Lin, Xin Liu, Ying-Hong Wang. Stilbene derivatives from Gnetum cleistostachyum. Journal of Asian Natural Products Research, vol. 7, issue 2, pp. 131-137, 2005. https://doi.org/10.1080/10286020310001625102
[14] B. Vermes, O. Seligmann, H. Wagner. Synthesis of biologically active tetrahydro-furofuranlignan-(syringin, pinoresinol)- mono- and bis-glucosides. Phytochemistry, vol. 30, issue 9, pp. 3087-3089, 1991. https://doi.org/10.1016/S0031-9422(00)98258-X