Continuous Research on the Extraction of Stilbenes from Gnetum montanum Markgr. in Vietnam
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Abstract
Gnetum montanum Markgr. belongs to the Gnetaceae family. Gnetum montanum Markgr. is distributed in the northern mountainous parts of Vietnam and is used as a Vietnamese herbal medicine for the treatment of rheumatoid arthritis, muscular strain and malaria. Previous phytochemical investigations on Gnetum plants have revealed an abundance of flavonoids and stilbenoids. With the goal of isolating compounds from this species in Vietnam, in the continous phytochemical investigation of stem of Gnetum montanum Markgr., we used extraction methods with increasing polar solvents and modern chromatography methods such as thin-layer chromatography (TLC), column chromatography (CC), and high-performance liquid chromatography (HPLC). They were two dimeric stilbenes gneafricanin F (1), gnetuhainin Q (2) together with a stilbene 2,3', 5'-trihydoxy-trans-stilbene (3) and a flavonoid homoeriodictyol (4). Their structures were elucidated by ESI-MS, 1D-NMR, and 2D-NMR combined with comparison with published spectral data.
Keywords
Gnetum montanum Markgr., stilbenoids, gneafricanin F, gnetuhainin Q, 2,3',5'-trihydoxy-trans-stilbene, homoeriodictyol
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References
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